
Bone Microarchitecture Analysis for MicroCT Data
The Bone Micro Analysis (BMA) module is available as an add-on for Analyze. BMA is a powerful pre-clinical research application designed for the evaluation of microCT data. The module provides the ability to process long bone specimens and isolate 3D samples of cortical bone, trabecular bone and trabecular tissue. It generates an extensive set of bone measurements as described by Bouxsein et al.
BMA provides automatic and user-guided isolation of bone from non-bone tissue and identification of both cortical and trabecular bone. The module uses the segmented regions to automatically drive the calculation of common bone measurements that provide a quantitative description of bone microarchitecture. The specific measurements for trabecular and cortical bone made by the BMA module are listed below.
Bone Microarchitecture Analysis Workflow
Preprocessing
The BMA add-on module requires that long bone specimens are isovolumetric. If the image data contains multiple bones the bone of interest must be isolated and orientated into the correct anatomical orientation. All tools needed for data preprocessing are provided with Analyze.

Cortical Bone Segmentation
Once the image data is loaded the BMA add-on will conduct a preliminary segmentation which will allow the module to identify the cortical shell, cortical pores and trabecular tissue regions.

Trabecular Bone Segmentation
Upon user approval the add-on will now complete the segmentation process by identifying the trabecular bone in the trabecular region. Two new regions, the trabecular bone and intra-trabecular space will be derived.

Calculate Bone Measurements
Measurements are automatically calculated for the trabecular and cortical bone and output in several comma-separated value (.csv) files. A utility is also provided to convert CT numbers (HUs) to Bone Mineral Density (BMD) in units of mg/CC.



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